In the match that could go either way, Santos, who won their opening encounter 2-0 against Mountain View last week, will start the more in-form team while Cavalier, who lost 1-0 to the Jamaica Defence Force (JDF) in their opener, will be seeking to enter the winners column.
Elsewhere, relegated premier league outfit, August Town, who registered the biggest win in last week's opening round - a 6-0 thumping of Liguanea - will seek win number two when they take Real Mona, who lost to Bull Bay in their opener, at Buttercup Park.
Hard-fought win
Duhaney Park, who recorded a hard-fought 1-0 away win to Police National, will take on another set of law enforcement officers when they play the JDF, while Police National will travel to winless Marverley/ Hughenden.
Bull Bay, who finished second last season, will seek to make good their perfect start when they travel to Mountain View at Excelsior High, while Constant Spring, who edged neighbours Marverley/Hughenden in their opener, will tackle Liguanea at Jamaica College.
All games are scheduled to start at 3:00 p.m.